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KMID : 0616620030090010037
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Journal of Soonchunhyang Medical College
2003 Volume.9 No. 1 p.37 ~ p.43
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Prognostic Significance Steroid Hormone Receptor Status and Cyclin D1 Overexpression in Young Women with Breast Cancer
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Choi Doo-Ho
Lee Min-Hyuk
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Abstract
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Background and Objects: The purpose of this study was to determine the prognostic significance of estrogen receptor (ER) and progesterone receptor (PR) status and cyclin D1 overexpression in Korean women with early-onset breast cancer.
Materials and Methods: Sixty women diagnosed and treated with breast cancer at the age of 45 or younger at Soonchunhyang University Hospital were entered for this study. The median age was 37years and follow-up periods were between 80 and 30 months. Paraffin embedded blocks of the primary tumor were processed for immunohistochemical staining of ER, PR and cyclin D1. Close follow-up data were entered in the database for analysis of the prognostic signifinance.
Results: The proportion of the tumors staining positive for ER, PR and cyclin D1 were 45.7%, 44.1% 40.7%, respectively. No association was found between immunoreactivity of these markes and axiliary lymph node metastais. The expression of ER correlated with expression of PR and cyclin D1(p<0.001). Lymph node metastasis revealed a poor prognostic factor, but these 3 markers were not prognostic factors in these cohorts of patients, although trends toward poor outcome were observed among patients with negative staining.
Conclusions: Cyclin D1 and steroid hormone receptor status were not significant prognostic factors in young women with breast cancer. Large-scaled studies are needed for evaluation of prognostic significance of these immunohistochemical markers in Korean women with early-onset breast cancer.
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KEYWORD
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Hormone Receptor, cyclin D1, Young Women, Breast Cancer
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